Sepsis is a complex whole-body inflammatory state caused by severe infection by bacteria, fungi or other microorganisms. Severe sepsis is accompanied by single or multiple organ dysfunction or failure, often leading to death. Cytokines and other substances of the innate immune system are released into the blood to combat the infection. This results in a systemic inflammatory state with formation of thrombi, bleeding and leaky vessels. It proceeds finally in impaired blood flow which damages the organs by depriving them of nutrients and interferes with oxygen supply.
The severity of organ damage and sepsis is often estimated from clinical risk stratification scores such as the Sequential Organ Failure Assessment (SOFA) Score 1, APACHE II („Acute Physiology and Chronic Health Evaluation II“) 2, or MEDS (Mortality in Emergency Department Sepsis).3
PATHFASTTM determines the quantity of Troponin I, NTproBNP, D-Dimer, hsCRP, Myoglobin, HCG and CK-MB mass from one single whole blood sample. The quantitative data of the parallel analyses provide results within minutes, which facilitate the therapeutical decision. Basis for a safe diagnosis on-site for patients with acute coronary syndrome, venous thromboembolism and suspected coronary insufficiency.